FAQ

Frequently asked questions


1

What is STIOLTO RESPIMAT?

STIOLTO RESPIMAT (tiotropium bromide and olodaterol) is a once-daily, long-acting maintenance treatment that helps adults breathe better and control COPD symptoms—all day, and all night. It is a combination of 2 types of medicines. It contains tiotroprium, an anticholinergic, or long-acting muscarinic antagonist (LAMA), and olodaterol, a long-acting beta2-agonist (LABA). LAMA and LABA medicines help the muscles around the airways in your lungs stay relaxed to prevent COPD symptoms, such as wheezing, cough, chest tightness, and shortness of breath.

STIOLTO is not for the sudden symptoms of COPD. You should always have a rescue medicine with you. It is not for people with asthma, and should not be used by children or anyone who is allergic to any of the ingredients in STIOLTO.

STIOLTO has been clinically proven to significantly increase lung function.

For more about STIOLTO, please see What is STIOLTO?

2

How can STIOLTO RESPIMAT help?

Can decrease the use of rescue inhalers

Can decrease the use of rescue inhalers

A slow-moving mist helps you inhale the medicine

Delivers a slow-moving mist to help you inhale the medicine

Can decrease the use of rescue inhalers

Is steroid-free

STIOLTO helps open airways in 5 minutes and for 24 hours. STIOLTO is not for the relief of sudden symptoms of COPD. Always carry a rescue inhaler with you.

Helps open airways in just 5 minutes* AND lasts a full 24 hours

*STIOLTO is not for the relief of sudden symptoms of COPD. You should always carry a rescue inhaler with you.

For more on how STIOLTO can help, please see What is STIOLTO?

3

What is the difference between rescue and maintenance treatment?

While rescue inhalers go to work right away, and you can feel their effect within minutes, maintenance treatment can control your COPD symptoms long term. Maintenance treatments, like STIOLTO RESPIMAT, are long-acting medicines you take once daily to manage your COPD symptoms.

4

How do I use STIOLTO RESPIMAT?

Using the STIOLTO RESPIMAT inhaler for daily dosing

After preparing and priming the inhaler, patients can remember the steps for daily use with "T.O.P.":

Turn the clear base

Turn: the clear base

Open the cap

Open: the green cap and close your lips around the mouthpiece

Press the dose-release button

Press: the dose-release button and inhale the mist

These steps must be performed 2 times to receive the proper dose of medication.

STIOLTO must be prepared and primed before first use. Please see full Instructions for Use for additional details on preparing and priming the inhaler, and how to use the inhaler for daily dosing.

5

I use oxygen. Will I still need to use it with STIOLTO RESPIMAT?

If your doctor has prescribed oxygen for your COPD, you should still take it as prescribed after starting STIOLTO unless your doctor tells you otherwise.

6

What is chronic obstructive pulmonary disease (COPD)?

COPD is a chronic, progressive lung condition that makes it harder to breathe. COPD includes 2 major components. One is chronic bronchitis, which is inflammation of the airways. The other is emphysema, which is damage to your air sacs (alveoli). You may have one or the other or both. These make it difficult to get air out of your lungs and new air back in. While there is no cure for COPD, with lifestyle changes and medication, you may be able to breathe better and manage your symptoms.

7

What are the symptoms of COPD?

Some symptoms of COPD include:

  • Shortness of breath
  • Cough
  • Chest tightness
  • Wheezing

For more symptoms, please see COPD Symptoms and Progression.

8

Can I prevent my COPD from getting worse?

The only proven way to slow COPD is to quit smoking. Quitting smoking is the only thing you can do to slow the progression of COPD, but STIOLTO RESPIMAT can still help you breathe better. Once-daily STIOLTO has been shown to help heavy smokers (those who smoked a pack a day for 10 years) breathe better. Ask your doctor if STIOLTO is right for you.

9

What can trigger my COPD symptoms?

Many things can cause COPD symptoms to suddenly worsen. Triggers include:

  • Cigarette smoke and smoking
  • Extreme hot or cold weather
  • Air pollution

If you have COPD, it’s important to be familiar with common triggers so you can avoid exposure to them.

10

Can breathing exercises help my COPD?

Yes! Ask your doctor about ways to help you breathe more efficiently during the day. He or she can also recommend you relaxation techniques to use when you’re short of breath.

11

Can I still exercise with COPD?

In many cases, yes. In fact, exercise can have many benefits for a COPD sufferer. Some low-impact exercise, such as walking, stretching, and gentle strengthening exercises can help decrease shortness of breath and improve your overall level of energy. Talk to your doctor before starting any new activities. Even with COPD, it may be possible and helpful to find an exercise program that works for you.

12

What else can I do to better manage my COPD?

There’s a lot you can do to keep COPD under control. For instance:

  • Avoid triggers, such as dust or smoke, that can irritate your lungs
  • Get vaccinated against the flu and pneumonia
  • Avoid germs during cold and flu season
  • Get your family on board with encouragement and support
  • Take all medicines as directed by your doctor

Want to know more about managing COPD? Sign up now to receive FREE tips and tools for keeping COPD in check.

13

What financial assistance is available for me?

You may be eligible to pay as little as $0 copay for one year through the STIOLTO RESPIMAT Savings Card program. In addition, the BI Cares Foundation may be able to help those who are covered by federal or state prescription programs or who have no prescription coverage and need financial assistance.

Learn more about these programs with a Savings Card.

INDICATION

STIOLTO® RESPIMAT® (tiotropium bromide and olodaterol) Inhalation Spray is a prescription medicine used long term, two puffs once each day, in controlling symptoms in adults with chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both.

STIOLTO contains the anticholinergic, tiotropium, and the long-acting beta2-adrenergic agonist (LABA), olodaterol. STIOLTO works by helping the muscles around the airways in your lungs stay relaxed to prevent symptoms, such as wheezing, cough, chest tightness, and shortness of breath.

STIOLTO is not for treating sudden symptoms of COPD. Always have a rescue medicine with you to treat sudden symptoms. If you do not have a rescue inhaler, contact your healthcare provider to have one prescribed for you.

Do not use STIOLTO if you have asthma. STIOLTO is approved to treat COPD only.

IMPORTANT SAFETY INFORMATION

People with asthma who take long-acting beta2-agonist (LABA) medicines, such as olodaterol, (one of the medicines in STIOLTO), have an increased risk of death from asthma problems.

More Important Safety Information

INDICATION

STIOLTO® RESPIMAT® (tiotropium bromide and olodaterol) Inhalation Spray is a prescription medicine used long term, two puffs once each day, in controlling symptoms in adults with chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both.

STIOLTO contains the anticholinergic, tiotropium, and the long-acting beta2-adrenergic agonist (LABA), olodaterol. STIOLTO works by helping the muscles around the airways in your lungs stay relaxed to prevent symptoms, such as wheezing, cough, chest tightness, and shortness of breath.

STIOLTO is not for treating sudden symptoms of COPD. Always have a rescue medicine with you to treat sudden symptoms. If you do not have a rescue inhaler, contact your healthcare provider to have one prescribed for you.

Do not use STIOLTO if you have asthma. STIOLTO is approved to treat COPD only.

 

IMPORTANT SAFETY INFORMATION

IMPORTANT SAFETY INFORMATION (continued)

People with asthma who take long-acting beta2-agonist (LABA) medicines, such as olodaterol, (one of the medicines in STIOLTO), have an increased risk of death from asthma problems. It is not known if LABA medicines, such as olodaterol (one of the medicines in STIOLTO), increase the risk of death in people with COPD. STIOLTO has been approved for chronic obstructive pulmonary disease (COPD) only. STIOLTO is NOT to be used in asthma.

Do not use STIOLTO if you are allergic to tiotropium, ipratropium, atropine or similar drugs, olodaterol, or any ingredient in STIOLTO. Symptoms of a serious allergic reaction may include rash, hives, swelling of the face, mouth, and tongue, and breathing problems. Call your healthcare provider or get emergency medical care if you get any symptoms of a serious allergic reaction. Do not use STIOLTO for treating sudden breathing problems. Always have a rescue inhaler with you to treat sudden symptoms.

Do not use STIOLTO more often or at higher doses than prescribed by your doctor. Do not use STIOLTO with other LABAs or anticholinergics. Get emergency medical care if your breathing problems worsen quickly or if you use your rescue inhaler but it does not relieve your breathing problems. Call your healthcare provider if breathing problems worsen over time while using STIOLTO.

Tell your doctor about all your medical conditions including heart problems, high blood pressure, seizures, thyroid problems, diabetes, kidney problems, glaucoma, enlarged prostate, and problems passing urine.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines (including eye drops), vitamins, and herbal supplements. STIOLTO may interact with other medicines which may cause serious side effects.

STIOLTO can cause serious side effects, including sudden shortness of breath that may be life threatening, fast or irregular heartbeat, increased blood pressure, chest pain, high blood sugar, or low blood potassium that may cause muscle spasms or weakness or abnormal heart rhythm. If any of these happens, stop taking STIOLTO and seek immediate medical help.

STIOLTO can cause new or worsening eye problems including narrow-angle glaucoma, and can increase the pressure in your eyes, which can cause the following symptoms: eye pain, blurred vision, seeing halos or colored images along with red eyes. If you have any of these symptoms, stop taking your medicine and call your doctor right away.

STIOLTO can cause new or worsened urinary retention. Symptoms of urinary retention may include difficulty passing urine, painful urination, urinating frequently, or urinating in a weak stream or drips. If you have any of these symptoms, stop taking your medicine and call your doctor right away.

STIOLTO is for oral inhalation only. The STIOLTO cartridge is only intended for use with the STIOLTO RESPIMAT inhaler.

Do not spray STIOLTO into your eyes.

The most common side effects of STIOLTO are runny nose, cough, and back pain.

Tell your healthcare provider about any side effect that bothers you or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

Read the step-by-step patient Instructions for Use for STIOLTO RESPIMAT before you use your inhaler.

Please see accompanying Medication Guide, Instructions for Use, and Full Prescribing Information, including boxed WARNING.